Speaking on Twitter, Kamiya responded to a fan first by saying that "unexpected developments" are waiting for Bayonetta fans. Just that alone would raise an eyebrow, but Kamiya followed up with a much more direct statement. He says that he doesn't think what's coming should be unexpected at all, but that the ending of Bayonetta 3 "wasn't conveyed correctly to everyone." With that in mind, he thinks, "Bayo 4 will be an unexpected development for everyone."
I'm going to remain doubtfully optimistic about it. I think I can already tell what's going to happen probably if they're going the route that doesn't piss people off.