I use it on Pokemon Crystal, it's one of my favorite games, and can get really weird in some cases. I normally Nuzlocke run it and it just gets outta control.
I've seen a lot of Randomizer /Randomizer Nuzlocke playthroughs on Youtube, but I've personally never done one. It would make the game more interesting though. Maybe the next Pokemon game I LP will be a randomizer, just to spice it up.