IS YOUR BODY READY FOR SOME ACTUAL ADVICE!?!
EXCLUSIVE
Uncharted (1+2)
Katamari Forever
The ICO collection (whenever the hell it comes out)
Metal Gear Solid 4 (only get it if you've played all of the other ones)
Demon's Souls (try it before buying)
Killzone 2 or 3 (If you like BROWN N BLOOM GENERIC SHOOTAN')
3D Dot Game Heros (Its basically the first legend of zelda)
LittleBIGplanet 2 (trust me, you dont want to get the first. I have both and the second one is essentially first but better to say the least)
Heavy Rain (Only if you want to get into something serious)
The Ratchet and Clank games
The Last Guardian (its not out yet, but its definitely something to be looking forward to)
Portal 2 (I know its not an exclusive per say but the game comes with a downloadable copy of the game for the PC and its going to have free updates through steamcloud or something like that. The Xbox version will be missing both of these)
3RD PARTY
Marvel Vs Capcom 3 (If you like fightan games)
Dead Space (Its not that scary, unless you're some kind of manchild)
Dead Space 2 (If you liked the first)
Batman Arkham Asylum (Because THE GODDAMN BATMAN is in it)
Fallout New Vegas/3 (New Vegas is better story and writing/voice acting wise but has more bugs on the ps3, 3 has an awesome start but a pretty shallow plot and I personally liked the environment in this than in NV)
Mass Effect 2 (aka WAIFU SIMULATOR 2)
Bioshock 1+2 (The first is one of my favorite games of all time, it should be dirt cheep.
DOWNLOADABLE
EVERY GAME MADE BY THATGAMESTUDIO, look them up. They're awesome.
Fat Princess
MGS1
FFIX (or really any FF game that tickles your fancy)
Spyro
The Crash Games
Ape Escape
Bomberman Land
Castlevania
Harvest Moon
Bomberman '64
Sonic Adventure
Back to the Future THE GAME
Castle Crashers
Dead Nation
Mega Man 9+10
Noby Noby Boy
Prince of Persia
Sonic the hedgehog 1+2
Have fun