Assassin's Creed III, Pikmin 3, Ghost Recon Online, Tekken, Aliens: Colonial Marines, Batman Arkham City, and... perhaps a Mario game, something like that New Super Mario Bros. Wii demo last year.
Most of these games were announced last year and have been in development for some time, especially games like AC3 and Batman Arkham City.
Realistically? I haven't a clue. Quite possibly none of the games thus-far revealed (it's not as if many games have been revealed yet).
I fully expect Pikmin 3 to come out within 2 months of launch, but I don't know whether it will actually be a launch title (might be, might not; I haven't a clue).