Alienware made the world's largest mechanical keyboard and mouse lol:
With a five-meter-long keyboard and massive mouse it took all five members of Team Liquid's world-class DOTA team to use it to control a single character.
While it doesn't look practical, you can tell the people are having a great time with learning how to use the keys & mouse.
I don't think I would however. You'd need several people with something liken to a hive mind so that everybody is working together.