I think USB mouses may more likely have problems with USB keyboard and mouse compared to PS/2 keyboards and mouse. There are probably hundreds of different USB keyboard and mouse models while PS/2 keyboard and mouses are usually compatible with most Windows operating systems like Windows 10, 7, Vista, XP, and 8 in my experience.
PS/2 is also an older technology standard where most of the Windows problems with PS/2 are fixed.